GWAS-related eQTLs across different cancer types
We identified 337,131 eQTLs that overlap with GWAS linkage disequilibrium (LD) regions (r² ≥ 0.5).
|
Cancer type
|
eQTL type
|
tagSNP
|
Gene position (hg19)
|
p-value
|
|||||||
|---|---|---|---|---|---|---|---|---|---|---|---|
| BLCA | cis | rs2832077 | 1 | rs2832077 | chr21:30141021 | N6AMT1 | chr21:30244513-30257693:- | -0.29 | -4.76 | 2.75E-6 | Cognitive test performance |
| BLCA | cis | rs11088226 | 1 | rs2833888 | chr21:33927560 | TCP10L | chr21:33947152-33957845:- | -0.36 | -4.78 | 2.52E-6 | Gastritis |
| BLCA | cis | rs11088226 | 1 | rs2833889 | chr21:33927768 | TCP10L | chr21:33947152-33957845:- | 0.38 | 5.05 | 6.95E-7 | Gastritis |
| BLCA | cis | rs11088226 | 1 | rs2833890 | chr21:33927886 | TCP10L | chr21:33947152-33957845:- | 0.35 | 4.72 | 3.35E-6 | Gastritis |
| BLCA | cis | rs1003719 | 1 | rs2835607 | chr21:38491973 | PIGP | chr21:38437664-38445458:- | -0.31 | -5.42 | 1.07E-7 | Eye color traits |
| BLCA | cis | rs1003719 | 1 | rs2835607 | chr21:38491973 | TTC3 | chr21:38445571-38575406:+ | 0.25 | 5.15 | 4.28E-7 | Eye color traits |
| BLCA | cis | rs1003719 | 1 | rs2835608 | chr21:38493455 | PIGP | chr21:38437664-38445458:- | -0.3 | -5.3 | 1.95E-7 | Eye color traits |
| BLCA | cis | rs1003719 | 1 | rs2835608 | chr21:38493455 | TTC3 | chr21:38445571-38575406:+ | 0.25 | 5.14 | 4.38E-7 | Eye color traits |
| BLCA | cis | rs6951245 | 1 | rs28379681 | chr7:1070539 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.31 | 2.12E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs2839186 | 1 | rs2839181 | chr21:47685939 | C21orf57 | chr21:47706267-47717664:+ | -0.27 | -5.02 | 8.03E-7 | Testicular germ cell tumor |
| BLCA | cis | rs2839186 | 1 | rs2839186 | chr21:47690068 | C21orf57 | chr21:47706267-47717664:+ | -0.3 | -5.52 | 6.2E-8 | Testicular germ cell tumor |
| BLCA | cis | rs8133949 | 1 | rs2839434 | chr21:43418905 | C21orf121 | chr21:43442113-43445060:+ | 0.32 | 4.5 | 8.85E-6 | Hand grip strength |
| BLCA | cis | rs2143950 | 1 | rs28399702 | chr14:35625217 | PPP2R3C | chr14:35554679-35591679:- | 0.24 | 4 | 7.55E-5 | Atopic dermatitis |
| BLCA | cis | rs6951245 | 1 | rs28399710 | chr7:1070631 | ZFAND2A | chr7:1192544-1199855:- | -0.37 | -4.31 | 2.12E-5 | C-reactive protein levels or total cholesterol levels (pleiotropy) |
| BLCA | cis | rs10935120 | 1 | rs28409322 | chr3:134252385 | ANAPC13 | chr3:134196547-134204865:- | -0.5 | -7.97 | 1.89E-14 | Height |